ABSTRACT
It is a long journey to create a new medicine from discovering the lead to market, which deal with various fields and aspects. There are also many ways and entrances or starting points for the creation of a new medicine. In this article, the following aspects including the ways from traditional Chinese materia medica, folk herbal medicine, active components, and structure modification involved in new medicine creation were discussed. Biomimetic syntheses, metabolites, and key technologies to affect the creative medicine were also summarized based on author's experiences. It is expected to be referenced information and inspired for the colleagues.
ABSTRACT
<p><b>AIM</b>A series of new 1,4-pentadien-3-one derivatives were synthesized to search for new Eight novel hydroxylated non-steroidal anti-inflammatory drugs (NSAIDs) with potent activity.</p><p><b>METHODS</b>E,E-1-(3'-indolyl)-5-( substituted phenyl)-1,4-pentadien-3-one derivatives were synthesized by means of aldol condensation and characterized by 1H NMR, ESI-MS and element analysis. Their anti-inflammatory activity in vitro were evaluated.</p><p><b>RESULTS</b>Preliminary in vitro pharmacological tests showed that all compounds exhibited anti-inflammatory activity.</p><p><b>CONCLUSION</b>Compounds 4d and 4e exhibited potent anti-inflammatory activity and their anti-inflammatory activity was comparable to resveratrol, and were worthy of further study.</p>